Nearly two dozen people are facing restrictions on their movements following recent shootings in the underworld gang war in Sydney's southwest.
The move by police comes as officers brace for a bloody gangland war following last week's brazen daytime shooting of Mejid Hamzy - the brother of notorious criminal and Brothers For Life founder Bassam Hamzy.
Detective Superintendent Robert Critchlow said police had slapped public safety orders on 22 people in a bid to disrupt criminal networks in Sydney's southwest.
Strike Force Courier is investigating the execution of Mejid Hamzy, which was followed by a prison stabbing between two members of Brothers For Life.
Mejid and Bassam Hamzy's cousin Mohammed Hamzy was stabbed during the incident at the John Morony Correctional Centre at Windsor.
Det Supt Critchlow said the public safety orders had imposed no-go zones on the 22 men and restricted who they could associate with, for 72 hours.
The orders also mean police can search the men's cars and houses whenever they want.
"Well the time to muck about has passed. We've got people dying on the streets and it's got to stop," he told Sydney radio 2GB on Tuesday.
"We're sick of this behaviour ... and we won't tolerate ongoing conduct endangering the whole community," he said.
"We will enforce those most vigorously, which means we'll be going through doors all hours of the day and night."
Police are also cracking down on illegal gun possession across suburbs in Sydney's southwest .
Firearm Prohibition Orders made by the police commissioner prohibit a person from bearing a firearm, firearm parts, or ammunition on the basis that it is not in the public interest to do so.
Australian Associated Press